Ontology highlight
ABSTRACT:
SUBMITTER: Pearson AJ
PROVIDER: S-EPMC7037328 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Pearson Adam J AJ Fullwood Paul P Toro Tapia Gabriela G Prise Ian I Smith Michael P MP Xu Qiuping Q Jordan Allan A Giurisato Emanuele E Whitmarsh Alan J AJ Francavilla Chiara C Tournier Cathy C
International journal of molecular sciences 20200131 3
The extracellular signal-regulated protein kinase 5 (ERK5) is a non-redundant mitogen-activated protein kinase (MAPK) that exhibits a unique C-terminal extension which comprises distinct structural and functional properties. Here<i>,</i> we sought to elucidate the significance of phosphoacceptor sites in the C-terminal transactivation domain of ERK5. We have found that Thr<sup>732</sup> acted as a functional gatekeeper residue controlling C-terminal-mediated nuclear translocation and transcripti ...[more]