Practical Guidance in Genome-Wide RNA:DNA Triple Helix Prediction.
Ontology highlight
ABSTRACT:
SUBMITTER: Matveishina E
PROVIDER: S-EPMC7037363 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Practical Guidance in Genome-Wide RNA:DNA Triple Helix Prediction.
Matveishina Elena E Antonov Ivan I Medvedeva Yulia A YA
International journal of molecular sciences 20200128 3
Long noncoding RNAs (lncRNAs) play a key role in many cellular processes including chromatin regulation. To modify chromatin, lncRNAs often interact with DNA in a sequence-specific manner forming RNA:DNA triple helices. Computational tools for triple helix search do not always provide genome-wide predictions of sufficient quality. Here, we used four human lncRNAs (MEG3, DACOR1, TERC and HOTAIR) and their experimentally determined binding regions for evaluating triplex parameters that provide the ...[more]
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