The Novel Arylamidine T-2307 Demonstrates In Vitro and In Vivo Activity against Candida auris.
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ABSTRACT:
SUBMITTER: Wiederhold NP
PROVIDER: S-EPMC7038306 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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The Novel Arylamidine T-2307 Demonstrates <i>In Vitro</i> and <i>In Vivo</i> Activity against Candida auris.
Wiederhold Nathan P NP Najvar Laura K LK Jaramillo Rosie R Olivo Marcos M Patterson Hoja H Connell April A Fukuda Yoshiko Y Mitsuyama Junichi J Catano Gabriel G Patterson Thomas F TF
Antimicrobial agents and chemotherapy 20200221 3
The <i>in vitro</i> and <i>in vivo</i> activity of the arylamidine T-2307 against <i>Candida auris</i> was evaluated. T-2307 demonstrated <i>in vitro</i> activity (MIC ranges ≤ 0.008 to 0.015 μg/ml at 50% inhibition; 0.125 to >4 μg/ml at 100% inhibition). Treatment with T-2307 (3 mg/kg subcutaneous [SC] once daily) also significantly improved survival (70% at 21 days postinfection) and reduced kidney fungal burden (5.06 log<sub>10</sub> CFU/g) compared to control (0% survival and 7.09 log<sub>10 ...[more]
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