Ontology highlight
ABSTRACT:
SUBMITTER: Jia Y
PROVIDER: S-EPMC7038627 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Jia Yiyang Y Guo Yantong Y Jin Qiu Q Qu Huinan H Qi Da D Song Peiye P Zhang Xiaoli X Wang Xinqi X Xu Wenhong W Dong Yuan Y Liang Yingying Y Quan Chengshi C
Journal of experimental & clinical cancer research : CR 20200224 1
<h4>Background</h4>We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In this study, we aim to explain this confusing finding and delineate the role of CLDN6 in the breast cancer metastasis induced by hypoxia.<h4>Methods</h4>RNAi and ChIP assays were used to confirm that CLDN6 is transcriptional regulated by HIF-1α. mRNA seq and KEGG analysis ...[more]