ORP5 regulates PI(4)P on the lipid droplet: Novel players on the monolayer.

ABSTRACT: How the distinct lipid composition of organelles is determined and maintained is still poorly understood. In this issue, Du et al. (2019. J. Cell Biol.https://doi.org/10.1083/jcb.201905162) show that the lipid transfer protein ORP5 functions at ER-LD contact sites, regulating lipid droplet levels of phosphatidylserine and phosphatidylinositol-4-phosphate.

SUBMITTER: Renne MF 

PROVIDER: S-EPMC7039197 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature