Ontology highlight
ABSTRACT:
SUBMITTER: Buffone A
PROVIDER: S-EPMC7039198 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Buffone Alexander A Weaver Valerie M VM
The Journal of cell biology 20200101 1
Mechanical interactions between tumors and the extracellular matrix (ECM) of the surrounding tissues have profound effects on a wide variety of cellular functions. An underappreciated mediator of tumor-ECM interactions is the glycocalyx, the sugar-decorated proteins and lipids that act as a buffer between the tumor and the ECM, which in turn mediates all cell-tissue mechanics. Importantly, tumors have an increase in the density of the glycocalyx, which in turn increases the tension of the cell m ...[more]