Ontology highlight
ABSTRACT:
SUBMITTER: Sharma P
PROVIDER: S-EPMC7039210 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Sharma Priyanka P Parveen Sameena S Shah Lekha V LV Mukherjee Madhumita M Kalaidzidis Yannis Y Kozielski Anthony J AJ Rosato Roberto R Chang Jenny C JC Datta Sunando S
The Journal of cell biology 20200101 1
A variety of metastatic cancer cells use actin-rich membrane protrusions, known as invadopodia, for efficient ECM degradation, which involves trafficking of proteases from intracellular compartments to these structures. Here, we demonstrate that in the metastatic breast cancer cell line MDA-MB-231, retromer regulates the matrix invasion activity by recycling matrix metalloprotease, MT1-MMP. We further found that MT2-MMP, another abundantly expressed metalloprotease, is also invadopodia associate ...[more]