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Expanding the biological utility of bis-NHC gold(i) complexes through post synthetic carbamate conjugation.

ABSTRACT: We report the synthesis of a novel hydroxyl-functionalised heteroleptic bis-NHC gold(i) complex that permits conjugation to various amines via carbamate bond formation. The resulting derivatives were studied in vitro using cell proliferation assays and fluorescent microscopic imaging of human cancer cell lines.

SUBMITTER: Sen S 

PROVIDER: S-EPMC7039396 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Expanding the biological utility of bis-NHC gold(i) complexes through post synthetic carbamate conjugation.

Sen Sajal S   Li Yue Y   Lynch Vincent V   Arumugam Kuppuswamy K   Sessler Jonathan L JL   Arambula Jonathan F JF  

Chemical communications (Cambridge, England) 20190801 71

We report the synthesis of a novel hydroxyl-functionalised heteroleptic bis-NHC gold(i) complex that permits conjugation to various amines via carbamate bond formation. The resulting derivatives were studied in vitro using cell proliferation assays and fluorescent microscopic imaging of human cancer cell lines. ...[more]

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