Ontology highlight
ABSTRACT:
SUBMITTER: Kiss B
PROVIDER: S-EPMC7039531 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Kiss Bernhard B van den Berg Nynke S NS Ertsey Robert R McKenna Kelly K Mach Kathleen E KE Zhang Chiyuan Amy CA Volkmer Jens-Peter JP Weissman Irving L IL Rosenthal Eben L EL Liao Joseph C JC
Clinical cancer research : an official journal of the American Association for Cancer Research 20190319 12
<h4>Purpose</h4>Near-infrared photoimmunotherapy (NIR-PIT) is a localized molecular cancer therapy combining a photosensitizer-conjugated mAb and light energy. CD47 is an innate immune checkpoint widely expressed on bladder cancer cells, but absent from luminal normal urothelium. Targeting CD47 for NIR-PIT has the potential to selectively induce cancer cell death and minimize damage to normal urothelium.<h4>Experimental design</h4>The cytotoxic effect of NIR-PIT with anti-CD47-IR700 was investig ...[more]