Ontology highlight
ABSTRACT:
SUBMITTER: Hwang SH
PROVIDER: S-EPMC7039557 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Hwang Sun-Hong SH Bang Sunhoe S Kim Wonho W Chung Jongkyeong J
The Journal of biological chemistry 20200120 8
Cell growth is positively controlled by the phosphoinositide 3-kinase (PI3K)-target of rapamycin (TOR) signaling pathway under conditions of abundant growth factors and nutrients. To discover additional mechanisms that regulate cell growth, here we performed RNAi-based mosaic analyses in the <i>Drosophila</i> fat body, the primary metabolic organ in the fly. Unexpectedly, the knockdown of the <i>Drosophila von Hippel-Lindau</i> (<i>VHL</i>) gene markedly decreased cell size and body size. These ...[more]