Interstitial diffuse optical probe with spectral fitting to measure dynamic tumor hypoxia.

ABSTRACT: Understanding the dynamic nature of tumor hypoxia is vital for cancer therapy. The presence of oxygen within a tumor during radiation therapy increases the likelihood of local control. We used a novel interstitial diffuse optical probe to make real-time measurements of blood volume fraction and hemoglobin oxygen saturation within a tumor at a high temporal resolution. This device was initially characterized and benchmarked using a customized vessel designed to control hemoglobin oxygen saturation and blood volume in a solution of blood with different concentrations of an oxygen scavenger, tetrakis (hydroxymethyl) phosphonium chloride. The optical device was found to consistently monitor the changes in oxygen saturation and these changes correlated to the concentration of the oxygen scaveng

SUBMITTER: Fru LC 

PROVIDER: S-EPMC7039661 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature