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Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB.

ABSTRACT: Prior studies in predominantly European (Caucasian) populations have discovered common genetic variants (single nucleotide polymorphisms, SNPs) associated with leukocyte telomere length (LTL), but whether these same variants affect LTL in non-Caucasian populations are largely unknown. We investigated whether six genetic variants previously associated with LTL (TERC (rs10936599), TERT (rs2736100), NAF1 (7675998), OBFC1 (rs9420907), ZNF208 (rs8105767), and RTEL1 (rs755017)) are correlated with telomere length (TL) in peripheral blood mononuclear cells (PBMCs) in a cohort of Africans living with and without HIV and undergoing evaluation for tuberculosis (TB). We found OBFC1 and the genetic sum score of the effect alleles across all six loci to be associated with shorter TL (adjusted for age, gender, HIV status, and smoking pack-years (p?

SUBMITTER: Wang S 

PROVIDER: S-EPMC7039711 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB.

Wang Stephanie S   Chang Emily E   Byanyima Patrick P   Huang Peter P   Sanyu Ingvar I   Musisi Emmanuel E   Sessolo Abdul A   Davis J Lucian JL   Worodria William W   Huang Laurence L   Lin Jue J  

Journal of human genetics 20190806 10

Prior studies in predominantly European (Caucasian) populations have discovered common genetic variants (single nucleotide polymorphisms, SNPs) associated with leukocyte telomere length (LTL), but whether these same variants affect LTL in non-Caucasian populations are largely unknown. We investigated whether six genetic variants previously associated with LTL (TERC (rs10936599), TERT (rs2736100), NAF1 (7675998), OBFC1 (rs9420907), ZNF208 (rs8105767), and RTEL1 (rs755017)) are correlated with tel  ...[more]

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