Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leucocyte antigen locus.
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SUBMITTER: Parks T
PROVIDER: S-EPMC7039814 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leucocyte antigen locus.
Parks Tom T Elliott Katherine K Lamagni Theresa T Auckland Kathryn K Mentzer Alexander J AJ Guy Rebecca R Cartledge Doreen D Strakova Lenka L Connor Daniel O' DO Pollard Andrew J AJ Neville Matthew J MJ Mahajan Anubha A Ashrafian Houman H Chapman Stephen J SJ Hill Adrian V S AVS Sriskandan Shiranee S Knight Julian C JC
Genes and immunity 20190829 1
Invasive group A streptococcal (GAS) disease is uncommon but carries a high case-fatality rate relative to other infectious diseases. Given the ubiquity of mild GAS infections, it remains unclear why healthy individuals will occasionally develop life-threatening infections, raising the possibility of host genetic predisposition. Here, we present the results of a case-control study including 43 invasive GAS cases and 1540 controls. Using HLA imputation and linear mixed models, we find each copy o ...[more]
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