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Effects of Bacterial Translocation and Autophagy on Acute Lung Injury Induced by Severe Acute Pancreatitis.


ABSTRACT: Aim:To reveal the role of bacterial translocation (BT) and autophagy in severe acute pancreatitis-induced acute lung injury (SAP-ALI). Methods:Rats were separated into a control (sham-operation) group (n = 10) and a SAP group (n = 10) and a SAP group (. Results:Levels of TNF-?, IL-6, lipase, and amylase in the SAP group were significantly higher than those in the control group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (. Conclusions:BT can aggravate SAP-ALI with the increasing oxidative stress level, which may be related to the decrease of autophagy level.

SUBMITTER: Wang H 

PROVIDER: S-EPMC7040400 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Effects of Bacterial Translocation and Autophagy on Acute Lung Injury Induced by Severe Acute Pancreatitis.

Wang Hanlin H   Li Chang C   Jiang Yingjian Y   Li Hongbo H   Zhang Dianliang D  

Gastroenterology research and practice 20200213


<h4>Aim</h4>To reveal the role of bacterial translocation (BT) and autophagy in severe acute pancreatitis-induced acute lung injury (SAP-ALI).<h4>Methods</h4>Rats were separated into a control (sham-operation) group (<i>n</i> = 10) and a SAP group (<i>n</i> = 10) and a SAP group (.<h4>Results</h4>Levels of TNF-<i>α</i>, IL-6, lipase, and amylase in the SAP group were significantly higher than those in the control group (<i>P</i> < 0.01). Histopathological score and W/D ratio of the lung in the S  ...[more]

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