Late viral or bacterial respiratory infections in lung transplanted patients: impact on respiratory function.

ABSTRACT: BACKGROUND:Respiratory infections are a major threat for lung recipients. We aimed to compare with a monocentric study the impact of late viral and bacterial respiratory infections on the graft function. METHODS:Patients, who survived 6 months or more following lung transplantation that took place between 2009 and 2014, were classified into three groups: a viral infection group (VIG) (without any respiratory bacteria), a bacterial infection group (BIG) (with or without any respiratory viruses), and a control group (CG) (no documented infection). Chronic lung allograft dysfunction (CLAD) and acute rejection were analysed 6 months after the inclusion in the study. RESULTS:Among 99 included lung recipients, 57 (58%) had at least one positive virological respiratory sample during the study period. Patients were classified as follows: 38 in the VIG, 25 in the BIG (among which 19 co-infections with a virus) and 36 in the CG. The BIG presented a higher initial deterioration in lung function (p?=?0.05) than the VIG. But 6 months after the infection, only the VIG presented a median decrease of forced expiratory volume in 1?s; -?35?mL (IQR; -?340; +?80) in the VIG, +?140?mL (+?60;+?330) in the BIG and?+?10 (-?84;+?160) in the CG, p?

SUBMITTER: Dubert M 

PROVIDER: S-EPMC7041086 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature