Ontology highlight
ABSTRACT:
SUBMITTER: Zhang B
PROVIDER: S-EPMC7041245 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
BMC microbiology 20200224 1
<h4>Background</h4>The polyketide antibiotic 2,4-diacetylphloroglucinol (2,4-DAPG), produced by Pseudomonas fluorescens 2P24, is positively regulated by the GacS-GacA two-component system.<h4>Results</h4>Here we reported on the characterization of DsbA1 (disulfide oxidoreductase) as novel regulator of biocontrol activity in P. fluorescens. Our data showed that mutation of dsbA1 caused the accumulation of 2,4-DAPG in a GacA-independent manner. Further analysis indicated that DsbA1 interacts with ...[more]