Ontology highlight
ABSTRACT:
SUBMITTER: Collins KB
PROVIDER: S-EPMC7041690 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Collins Kerrie B KB Kang Hojin H Matsche Jacob J Klomp Jennifer E JE Rehman Jalees J Malik Asrar B AB Karginov Andrei V AV
The Journal of cell biology 20200201 2
Podosomes are compartmentalized actin-rich adhesions, defined by their ability to locally secrete proteases and remodel extracellular matrix. Matrix remodeling by endothelial podosomes facilitates invasion and thereby vessel formation. However, the mechanisms underlying endothelial podosome formation and function remain unclear. Here, we demonstrate that Septin2, Septin6, and Septin7 are required for maturation of nascent endothelial podosomes into matrix-degrading organelles. We show that podos ...[more]