Ontology highlight
ABSTRACT:
SUBMITTER: Zhang GC
PROVIDER: S-EPMC7041726 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Zhang Guang-Cong GC Yu Xiang-Nan XN Sun Jia-Lei JL Xiong Ju J Yang Yi-Jun YJ Jiang Xue-Mei XM Zhu Ji-Min JM
Aging 20200203 3
Upregulated ubiquitin-conjugating enzyme E2M (UBE2M) is associated with poor prognosis in malignancies; However, the phenotype and mechanism of action of UBE2M in hepatocellular carcinoma (HCC) remain elusive. Here, we report that UBE2M is overexpressed and correlated with poor prognosis in HCC patients. The UBE2M level is an independent prognostic factor for HCC patients. UBE2M knockdown inhibits HCC cell proliferation, migration, and invasion, whereas its overexpression has an opposite effect. ...[more]