Ontology highlight
ABSTRACT:
SUBMITTER: Cervello M
PROVIDER: S-EPMC7041742 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cervello Melchiorre M Emma Maria R MR Augello Giuseppa G Cusimano Antonella A Giannitrapani Lydia L Soresi Maurizio M Akula Shaw M SM Abrams Stephen L SL Steelman Linda S LS Gulino Alessandro A Belmonte Beatrice B Montalto Giuseppe G McCubrey James A JA
Aging 20200204 3
Hepatocellular carcinoma (HCC), is the sixth most frequent form of cancer and leads to the fourth highest number of deaths each year. HCC results from a combination of environmental factors and aging as there are driver mutations at oncogenes which occur during aging. Most of HCCs are diagnosed at advanced stage preventing curative therapies. Treatment in advanced stage is a challenging and pressing problem, and novel and well-tolerated therapies are urgently needed. We will discuss further adva ...[more]