Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in.

ABSTRACT:

Introduction

Lung clearance index (LCI) is a sensitive measure of early lung disease, but adoption into clinical practice has been slow. Challenges include the time taken to perform each test. We recently described a closed-circuit inert gas wash-in method that reduces overall testing time by decreasing the time to equilibration. The aim of this study was to define a normative range of LCI in healthy adults and children derived using this method. We were also interested in the feasibility of using this system to measure LCI in a community setting.

Methods

LCI was assessed in healthy volunteers at three hospital sites and in two local primary schools. Volunteers completed three washout repeats at a single visit using the closed circuit wash-in method (0.2% SF6 wash-in tracer

SUBMITTER: Horsley AR 

PROVIDER: S-EPMC7041809 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature