?11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery.
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ABSTRACT:
SUBMITTER: Rook ML
PROVIDER: S-EPMC7041949 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery.
Rook Matthew L ML Williamson Abby A Lueck John D JD Musgaard Maria M Maclean David M DM
eLife 20200207
Acid-sensing ion channels (ASICs) are neuronal sodium-selective channels activated by reductions in extracellular pH. Structures of the three presumptive functional states, high-pH resting, low-pH desensitized, and toxin-stabilized open, have all been solved for chicken ASIC1. These structures, along with prior functional data, suggest that the isomerization or flipping of the β11-12 linker in the extracellular, ligand-binding domain is an integral component of the desensitization process. To te ...[more]
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