Dataset Information

Residual inflammatory risk in coronary heart disease: incidence of elevated high-sensitive CRP in a real-world cohort.

ABSTRACT:

Background

Inflammation drives atherosclerosis and its complications. Anti-inflammatory therapy with interleukin 1 beta (IL-1?) antibody reduces cardiovascular events in patients with elevated high-sensitive C-reactive protein (hsCRP). This study aims to identify the share of patients with coronary heart disease (CHD) and residual inflammation who may benefit from anti-inflammatory therapy.

Methods

hsCRP and low-density lipoprotein (LDL) levels were determined in 2741 all-comers admitted to the cardiological ward of our tertiary referral hospital between June 2016 and June 2018. Patients without CHD, with acute coronary syndrome, chronic or recurrent systemic infection, use of immunosuppressant or anti-inflammatory agents, chronic inflammatory diseases, chemotherapy, terminal organ failure, traumatic injury and pregnancy were excluded.

Results

856 patients with stable CHD were included. 42.7% of those had elevated hsCRP???2 mg/l. Within the group of patients with LDL-cholesterol?ConclusionOne-third of all-comers patients with CHD showed increased levels of hsCRP despite a LDL-cholesterol

SUBMITTER: Peikert A

PROVIDER: S-EPMC7042185 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Publications

Residual inflammatory risk in coronary heart disease: incidence of elevated high-sensitive CRP in a real-world cohort.

Peikert Alexander A Kaier Klaus K Merz Julian J Manhart Lucas L Schäfer Ibrahim I Hilgendorf Ingo I Hehn Philipp P Wolf Dennis D Willecke Florian F Sheng Xia X Clemens Andreas A Zehender Manfred M von Zur Mühlen Constantin C Bode Christoph C Zirlik Andreas A Stachon Peter P

Clinical research in cardiology : official journal of the German Cardiac Society 20190719 3

<h4>Background</h4>Inflammation drives atherosclerosis and its complications. Anti-inflammatory therapy with interleukin 1 beta (IL-1β) antibody reduces cardiovascular events in patients with elevated high-sensitive C-reactive protein (hsCRP). This study aims to identify the share of patients with coronary heart disease (CHD) and residual inflammation who may benefit from anti-inflammatory therapy.<h4>Methods</h4>hsCRP and low-density lipoprotein (LDL) levels were determined in 2741 all-comers a ...[more]

PMID: 31325043

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Dataset Information

Residual inflammatory risk in coronary heart disease: incidence of elevated high-sensitive CRP in a real-world cohort.

Background

Methods

Results

Publications

Residual inflammatory risk in coronary heart disease: incidence of elevated high-sensitive CRP in a real-world cohort.

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