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Serum Activin A Levels and Renal Outcomes After Coronary Angiography.


ABSTRACT: Prevention for contrast-induced nephropathy (CIN) is limited by the lack of a single predictor. As activin A is upregulated in heart failure and chronic kidney disease, we aimed to clarify the association between activin A levels and renal outcomes after coronary angiography (CAG). This prospective observational study included 267 patients who received CAG between 2009 and 2015. CIN was defined as elevation of serum creatinine to >0.5?mg/dL or to >25% above baseline within 48?hours after CAG. During follow-up, laboratory parameters were measured every 3-6 months. Renal decline was defined as>2-fold increase in serum creatinine or initiation of dialysis. The patients were stratified into tertiles according to serum activin A levels at baseline. High activin A tertile was significantly associated more CIN and renal function decline compared to low activin A tertile (all p?

SUBMITTER: Tsai YL 

PROVIDER: S-EPMC7042345 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Serum Activin A Levels and Renal Outcomes After Coronary Angiography.

Tsai Yi-Lin YL   Chou Ruey-Hsing RH   Lu Ya-Wen YW   Liu Chung-Te CT   Huang Po-Hsun PH   Lin Shing-Jong SJ  

Scientific reports 20200225 1


Prevention for contrast-induced nephropathy (CIN) is limited by the lack of a single predictor. As activin A is upregulated in heart failure and chronic kidney disease, we aimed to clarify the association between activin A levels and renal outcomes after coronary angiography (CAG). This prospective observational study included 267 patients who received CAG between 2009 and 2015. CIN was defined as elevation of serum creatinine to >0.5 mg/dL or to >25% above baseline within 48 hours after CAG. Du  ...[more]

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