Ontology highlight
ABSTRACT: Objectives
To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. Materials and Methods. Two different experiments were performed. In the first experiment, hamsters' right buccal pouches in group A (n?=?10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (n?=?10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (.Results
The time of macroscopic neoplasm development was reduced when DM-DMBA coexposition was employed, finding tumors after 10-12 weeks of exposition. In addition, the frequency of histopathological lesions was higher.Conclusion
Immunomodulatory action of dexamethasone may reduce the time of oral squamous cell carcinoma (OSCC) induction and may increase the incidence of neoplasms developed.
SUBMITTER: Martinez B DA
PROVIDER: S-EPMC7042540 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Martínez B Diana A DA Barato Gómez Paola Andrea PA Iregui Castro Carlos Arturo CA Rosas Pérez Jaiver E JE
BioMed research international 20200213
<h4>Objectives</h4>To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. <i>Materials and Methods</i>. Two different experiments were performed. In the first experiment, hamsters' right buccal pouches in group A (<i>n</i> = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (<i>n</i> = 10) were painted three times per week with 7 ...[more]