Dataset Information

CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research.

ABSTRACT: The Chinese Imaging Genetics (CHIMGEN) study establishes the largest Chinese neuroimaging genetics cohort and aims to identify genetic and environmental factors and their interactions that are associated with neuroimaging and behavioral phenotypes. This study prospectively collected genomic, neuroimaging, environmental, and behavioral data from more than 7000 healthy Chinese Han participants aged 18-30 years. As a pioneer of large-sample neuroimaging genetics cohorts of non-Caucasian populations, this cohort can provide new insights into ethnic differences in genetic-neuroimaging associations by being compared with Caucasian cohorts. In addition to micro-environmental measurements, this study also collects hundreds of quantitative macro-environmental measurements from remote sensing and national survey databases based on the locations of each participant from birth to present, which will facilitate discoveries of new environmental factors associated with neuroimaging phenotypes. With lifespan environmental measurements, this study can also provide insights on the macro-environmental exposures that affect the human brain as well as their timing and mechanisms of action.

SUBMITTER: Xu Q

PROVIDER: S-EPMC7042768 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research.

Xu Qiang Q Guo Lining L Cheng Jingliang J Wang Meiyun M Geng Zuojun Z Zhu Wenzhen W Zhang Bing B Liao Weihua W Qiu Shijun S Zhang Hui H Xu Xiaojun X Yu Yongqiang Y Gao Bo B Han Tong T Yao Zhenwei Z Cui Guangbin G Liu Feng F Qin Wen W Zhang Quan Q Li Mulin Jun MJ Liang Meng M Chen Feng F Xian Junfang J Li Jiance J Zhang Jing J Zuo Xi-Nian XN Wang Dawei D Shen Wen W Miao Yanwei Y Yuan Fei F Lui Su S Zhang Xiaochu X Xu Kai K Zhang Long Jiang LJ Ye Zhaoxiang Z Yu Chunshui C

Molecular psychiatry 20191211 3

The Chinese Imaging Genetics (CHIMGEN) study establishes the largest Chinese neuroimaging genetics cohort and aims to identify genetic and environmental factors and their interactions that are associated with neuroimaging and behavioral phenotypes. This study prospectively collected genomic, neuroimaging, environmental, and behavioral data from more than 7000 healthy Chinese Han participants aged 18-30 years. As a pioneer of large-sample neuroimaging genetics cohorts of non-Caucasian populations ...[more]

PMID: 31827248

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Project description:Imaging genetics studies involving participants with major depressive disorder (MDD) have expanded. Nevertheless, findings have been inconsistent. Thus, we conducted a systematic review and meta-analysis of imaging genetics studies that enrolled MDD participants across major databases through June 30th, 2017. Sixty-five studies met eligibility criteria (N = 4034 MDD participants and 3293 controls), and there was substantial between-study variability in the methodological quality of included studies. However, few replicated findings emerged from this literature with only 22 studies providing data for meta-analyses (882 participants with MDD and 616 controls). Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met 'Met' (386 participants with MDD and 376 controls) or the 5-HTTLPR short 'S' (310 participants with MDD and 230 controls) risk alleles compared to non-carriers. Heterogeneity across studies was explored through meta-regression and subgroup analyses. Gender distribution, the use of medications, segmentation methods used to measure the hippocampus, and age emerged as potential sources of heterogeneity across studies that assessed the association of 5-HTTLPR short 'S' alleles and hippocampal volumes. Our data also suggest that the methodological quality of included studies, publication year, and the inclusion of brain volume as a covariate contributed to the heterogeneity of studies that assessed the association of the BDNF Val66Met 'Met' risk allele and hippocampal volumes. In exploratory voxel-wise meta-analyses, MDD participants carrying the 5-HTTLPR short 'S' allele had white matter microstructural abnormalities predominantly in the corpus callosum, while carriers of the BDNF Val66Met 'Met' allele had larger gray matter volumes and hyperactivation of the right middle frontal gyrus compared to non-carriers. In conclusion, few replicated findings emerged from imaging genetics studies that included participants with MDD. Nevertheless, we explored and identified specific sources of heterogeneity across studies, which could provide insights to enhance the reproducibility of this emerging field.

Dataset Information

CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research.

Publications

CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research.

Similar Datasets

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