Genetic Heritability of Pigmentary Glaucoma and Associations With Other Eye Phenotypes.

ABSTRACT:

Importance

Mechanisms behind pigmentary glaucoma, a form of early-onset glaucoma that may potentially lead to severe visual impairment or blindness, are poorly understood.

Objective

To calculate the single-nucleotide polymorphism (SNP) heritability of pigmentary glaucoma and identify genetic associations with the disease.

Design, setting and participants

This genome-wide association study included affected individuals from Germany and control participants from the United Kingdom. Genome-wide information was obtained for patients with pigmentary glaucoma and control participants free of glaucoma by using the Illumina Human Omni Express Exome 8v1-2 chip and genomic imputation. The SNP heritability of pigmentary glaucoma was estimated through a restricted maximum likelih

SUBMITTER: Simcoe MJ 

PROVIDER: S-EPMC7042905 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature