Ontology highlight
ABSTRACT:
SUBMITTER: Giri J
PROVIDER: S-EPMC7043065 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Giri Jayeeta J Das Rahul R Nylen Emily E Chinnadurai Raghavan R Galipeau Jacques J
Cell reports 20200201 6
Mesenchymal stromal cell (MSC)-based therapy for inflammatory diseases involves paracrine and efferocytotic activation of immunosuppressive interleukin-10<sup>+</sup> (IL-10<sup>+</sup>) macrophages. The paracrine pathway for MSC-mediated IL-10<sup>+</sup> macrophage functionality and response to tissue injury is not fully understood. In our present study, clodronate pre-treatment of colitic mice confirms the essential role of endogenous macrophages in bone-marrow-derived MSC (BM-MSC)-mediated c ...[more]