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Diabetes and Clinical Outcome in Patients With Metastatic Colorectal Cancer: CALGB 80405 (Alliance).


ABSTRACT: Background:Diabetes is a prognostic factor for some malignancies, but its association with outcome in patients with advanced or metastatic colorectal cancer (CRC) is less clear. Methods:This cohort study was nested within a randomized trial of first-line chemotherapy and bevacizumab and/or cetuximab for advanced or metastatic CRC. Patients were enrolled at 508 community and academic centers throughout the National Clinical Trials Network. The primary exposure was physician-documented diabetes at the time of enrollment. The primary endpoint was overall survival (OS); secondary endpoints were progression-free survival (PFS) and adverse events. Tests of statistical significance were two-sided. Results:Among 2326 patients, 378 (16.3%) had diabetes. The median follow-up time was 6.0?years. We observed 1973 OS events and 2173 PFS events. The median time to an OS event was 22.7?months among those with diabetes and 27.1?months among those without diabetes (HR = 1.27, 95% CI = 1.13 to 1.44; P?

SUBMITTER: Brown JC 

PROVIDER: S-EPMC7043296 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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<h4>Background</h4>Diabetes is a prognostic factor for some malignancies, but its association with outcome in patients with advanced or metastatic colorectal cancer (CRC) is less clear.<h4>Methods</h4>This cohort study was nested within a randomized trial of first-line chemotherapy and bevacizumab and/or cetuximab for advanced or metastatic CRC. Patients were enrolled at 508 community and academic centers throughout the National Clinical Trials Network. The primary exposure was physician-documen  ...[more]

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