Macrophage effector responses of horses are influenced by expression of CD154.
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ABSTRACT:
SUBMITTER: Sponseller BA
PROVIDER: S-EPMC7043372 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Macrophage effector responses of horses are influenced by expression of CD154.
Sponseller Brett A BA Clark Sandra K SK Gilbertie Jessica J Wong David M DM Hepworth Kate K Wiechert Sarah S Chandramani Prashanth P Sponseller Beatrice T BT Alcott Cody J CJ Bellaire Bryan B Petersen Andrew C AC Jones Douglas E DE
Veterinary immunology and immunopathology 20160826
Reactive intermediates contribute to innate immunity by providing phagocytes with a mechanism of defense against bacteria, viruses and parasites. To better characterize the role of CD154 in the production of reactive intermediates, we cloned and expressed recombinant equine CD154 (reqCD154) in Chinese Hamster Ovary (CHO). In co-culture experiments, CHO cells ectopically expressing reqCD154 elicited superoxide production in monocyte-derived macrophages (MDM). Collectively, our results indicate th ...[more]
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