Ontology highlight
ABSTRACT:
SUBMITTER: Hu L
PROVIDER: S-EPMC7044111 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Hu Linyi L Sun Yin Y Luo Jie J He Xiang X Ye Meihua M Li Gonghui G Zhang Yong Y Bai Jian J Zhang Dahong D Chang Chawnshang C
Oncogene 20191120 9
Prostate cancer (PCa) is the second leading cause of cancer death in men in America, and there are no curative options for metastatic castration-resistant prostate cancer (mCRPC). Docetaxel (DTX) has been used as a standard chemotherapy for the mCRPC. However, resistance to DTX is a significant clinical problem as half of patients fail to respond to therapy. The TR4 nuclear receptor has been reported to play an important role in PCa progression, however, its linkage to the DTX resistance remains ...[more]