Ontology highlight
ABSTRACT:
SUBMITTER: Lerche M
PROVIDER: S-EPMC7044518 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lerche Martina M Elosegui-Artola Alberto A Kechagia Jenny Z JZ Guzmán Camilo C Georgiadou Maria M Andreu Ion I Gullberg Donald D Roca-Cusachs Pere P Peuhu Emilia E Ivaska Johanna J
iScience 20200213 3
The link between integrin activity regulation and cellular mechanosensing of tissue rigidity, especially on different extracellular matrix ligands, remains poorly understood. Here, we find that primary mouse mammary gland stromal fibroblasts (MSFs) are able to spread efficiently, generate high forces, and display nuclear YAP on soft collagen-coated substrates, resembling the soft mammary gland tissue. We describe that loss of the integrin inhibitor, SHARPIN, impedes MSF spreading specifically on ...[more]