Ontology highlight
ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC7044678 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Zhou Xuechen X Hao Rui R Chen Chen C Su Zhipeng Z Zhao Linhong L Luo Zhuojuan Z Xie Wei W
Molecular therapy. Methods & clinical development 20200130
Intracellular antigen labeling and manipulation by antibodies have been long-thought goals in the field of cell research and therapy. However, a central limitation for this application is that antibodies are not able to penetrate into the cytosol of living cells. Taking advantages of small sizes and unique structures of the single-domain antibodies, here, we presented a novel approach to rapidly deliver the nanobody/variable domain of heavy chain of heavy-chain antibody (V<sub>H</sub>H) into liv ...[more]