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ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis.

ABSTRACT: OBJECTIVE:Hepatitis B virus (HBV) infection is a major public health problem worldwide. Several studies have reported that ABO blood groups may be associated with HBV infection. However, its association is still controversial. We performed a meta-analysis to investigate whether ABO blood groups were associated with HBV infection. DESIGN:Systematic review and meta-analysis. DATA SOURCES:Relevant studies available before 1 December 2019 were identified by searching PubMed, EMBASE, Web of Science, ScienceDirect and the Cochrane Library. ELIGIBILITY CRITERIA:All cross-sectional or cohort studies from which the data of ABO blood group distribution and HBV infection could be extracted. DATA EXTRACTION AND SYNTHESIS:Studies were identified and extracted by two reviewers independently. Risk ratios (RRs) and 95% CIs were pooled by random-effect models to quantify this association. RESULTS:Thirty-eight eligible articles including 241 868 HBV-infected subjects and 6 487?481 uninfected subjects were included. Overall, the risk of HBV infection had decreased by 8% in subjects with blood group B when compared with non-B blood group (RR=0.92, 95%?CI 0.86 to 0.98). In the subgroup analyses, the inverse relationship between blood group B and HBV infection remained stable in higher endemic areas (HBV prevalence ?5%), Asian people, larger sample size studies (?2000), general population and blood donors, lower middle income group and studies published before the year 2010. Additionally, subjects with blood group O had a 12% increased risk of HBV infection (RR=1.12, 95%?CI 1.01 to 1.24) in higher endemic areas. In the sensitivity analysis, the pooled risk estimates of blood group B and HBV infection were still stable. CONCLUSIONS:Our data suggested that the blood group B was associated with a lower risk of HBV infection. More research is needed to clarify the precise role of the ABO blood group in HBV infection to address the global question of HBV infection.

SUBMITTER: Jing W

PROVIDER: S-EPMC7045238 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis.

Jing Wenzhan W Zhao Siyu S Liu Jue J Liu Min M

BMJ open 20200202 1

<h4>Objective</h4>Hepatitis B virus (HBV) infection is a major public health problem worldwide. Several studies have reported that ABO blood groups may be associated with HBV infection. However, its association is still controversial. We performed a meta-analysis to investigate whether ABO blood groups were associated with HBV infection.<h4>Design</h4>Systematic review and meta-analysis.<h4>Data sources</h4>Relevant studies available before 1 December 2019 were identified by searching PubMed, EM ...[more]

PMID: 32014878

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Project description:BACKGROUND:Malaria clinical outcomes vary by erythrocyte characteristics, including ABO blood group, but the effect of ABO blood group on asymptomatic, uncomplicated and placental Plasmodium falciparum (P. falciparum) infection remains unclear. We explored effects of ABO blood group on asymptomatic, uncomplicated and placental falciparum infection in the published literature. METHODS:A systematic review and meta-analysis was performed using the preferred reporting items for systematic reviews and meta-analyses guidelines. Articles in Pubmed, Embase, Web of Science, CINAHL and Cochrane Library published before February 04, 2017 were searched without restriction. Studies were included if they reported P. falciparum infection incidence or prevalence, stratified by ABO blood group. RESULTS:Of 1923 articles obtained from the five databases (Embase?=?728, PubMed?=?620, Web of Science?=?549, CINAHL?=?14, Cochrane Library?=?12), 42 met criteria for systematic review and 37 for meta-analysis. Most studies (n?=?30) were cross-sectional, seven were prospective cohort, and five were case-control studies. Meta-analysis showed similar odds of uncomplicated P. falciparum infection among individuals with blood group A (summary odds ratio [OR] 0.96, 15 studies), B (OR 0.89, 15 studies), AB (OR 0.85, 10 studies) and non-O (OR 0.95, 17 studies) as compared to those with blood group O. Meta-analysis of four cohort studies also showed similar risk of uncomplicated P. falciparum infection among individuals with blood group non-O and those with blood group O (summary relative risk [RR] 1.03). Meta-analysis of six studies showed similar odds of asymptomatic P. falciparum infection among individuals with blood group A (OR 1.05), B (OR 1.03), AB (OR 1.23), and non-O (OR 1.07) when compared to those with blood group O. However, odds of active placental P. falciparum infection was significantly lower in primiparous women with non-O blood groups (OR 0.46, 95% confidence interval [CI] 0.23 - 0.69, I2 0.0%, three studies), particularly in those with blood group A (OR 0.41, 95% CI 0.003 - 0.82, I2 1.4%, four studies) than those with blood group O. CONCLUSIONS:This study suggests that ABO blood group may not affect susceptibility to asymptomatic and/or uncomplicated P. falciparum infection. However, blood group O primiparous women appear to be more susceptible to active placental P. falciparum infection.

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ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis.

Publications

ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis.

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