Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predicts poor prognosis in patients with breast cancer.

ABSTRACT: BACKGROUND:The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid malignancies. This study aimed to evaluate the prognostic impact of PNI changes in patients with breast cancer undergoing neoadjuvant chemotherapy (NAC). METHODS:We reviewed patients with breast cancer who underwent NAC and a subsequent surgery for breast cancer between 2005 and 2016. PNI before and after NAC were calculated using the following formula: 10?×?serum albumin (g/dl)?+?0.005?×?total lymphocyte count/mm3. The relationship between PNI and prognosis was retrospectively analyzed. RESULTS:In total, 191 patients were evaluated. There was no significant difference in disease-free survival (DFS) between the pre-NAC PNI high group and the pre-NAC PNI low group (cutoff: 53.1). However, PNI decreased in 181 patients (94.7%) after NAC and the mean PNI also significantly decreased after NAC from 52.6?±?3.8 pre-NAC to 46.5?±?4.4 post-NAC (p?

SUBMITTER: Oba T 

PROVIDER: S-EPMC7045374 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature