Ontology highlight
ABSTRACT:
SUBMITTER: Gamache TR
PROVIDER: S-EPMC7046327 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Gamache Timothy R TR Araki Yoichi Y Huganir Richard L RL
The Journal of neuroscience : the official journal of the Society for Neuroscience 20200201 8
SynGAP is a potent regulator of biochemical signaling in neurons and plays critical roles in neuronal function. It was first identified in 1998, and has since been extensively characterized as a mediator of synaptic plasticity. Because of its involvement in synaptic plasticity, SynGAP has emerged as a critical protein for normal cognitive function. In recent years, mutations in the <i>SYNGAP1</i> gene have been shown to cause intellectual disability in humans and have been linked to other neurod ...[more]