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Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy.


ABSTRACT: miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155-containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting FoxO3a in uremic mice.

SUBMITTER: Wang B 

PROVIDER: S-EPMC7046511 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy.

Wang Bin B   Wang Ze-Mu ZM   Ji Jia-Ling JL   Gan Weihua W   Zhang Aiqing A   Shi Hao-Jie HJ   Wang Hao H   Lv Linli L   Li Zuolin Z   Tang Taotao T   Du Jie J   Wang Xiaonan H XH   Liu Bi-Cheng BC  

JACC. Basic to translational science 20200115 2


miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155-containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting F  ...[more]

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