Ontology highlight
ABSTRACT:
SUBMITTER: Sahai E
PROVIDER: S-EPMC7046529 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Sahai Erik E Astsaturov Igor I Cukierman Edna E DeNardo David G DG Egeblad Mikala M Evans Ronald M RM Fearon Douglas D Greten Florian R FR Hingorani Sunil R SR Hunter Tony T Hynes Richard O RO Jain Rakesh K RK Janowitz Tobias T Jorgensen Claus C Kimmelman Alec C AC Kolonin Mikhail G MG Maki Robert G RG Powers R Scott RS Puré Ellen E Ramirez Daniel C DC Scherz-Shouval Ruth R Sherman Mara H MH Stewart Sheila S Tlsty Thea D TD Tuveson David A DA Watt Fiona M FM Weaver Valerie V Weeraratna Ashani T AT Werb Zena Z
Nature reviews. Cancer 20200124 3
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding ...[more]