Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity.
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ABSTRACT:
SUBMITTER: Jia XY
PROVIDER: S-EPMC7046851 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Alkaloid Constituents of Ficus hispida and Their Antiinflammatory Activity.
Jia Xin-Yu XY Wu Yong-Mei YM Li Jing-Ya JY Lei Chun C Hou Ai-Jun AJ
Natural products and bioprospecting 20200218 1
Four new alkaloids, ficuhismines A-D (1-4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1-2) or with a N-oxide motif (2-4) from the genus Ficus. Compound 2 showed potent inhibitory effect in nuclear factor-κB (NF-κB) pathway luciferase assay with IC<sub>50</sub> value of 0.52 ± 0.11 μM. ...[more]
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