Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model.
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ABSTRACT:
SUBMITTER: Zhong X
PROVIDER: S-EPMC7047331 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model.
Zhong Xiali X Harris Georgina G Smirnova Lena L Zufferey Valentin V Sá Rita de Cássia da Silveira E RCDSE Baldino Russo Fabiele F Baleeiro Beltrao Braga Patricia Cristina PC Chesnut Megan M Zurich Marie-Gabrielle MG Hogberg Helena T HT Hartung Thomas T Pamies David D
Frontiers in cellular neuroscience 20200221
Selective serotonin reuptake inhibitors (SSRIs) are frequently used to treat depression during pregnancy. Various concerns have been raised about the possible effects of these drugs on fetal development. Current developmental neurotoxicity (DNT) testing conducted in rodents is expensive, time-consuming, and does not necessarily represent human pathophysiology. A human, <i>in vitro</i> testing battery to cover key events of brain development, could potentially overcome these challenges. In this s ...[more]
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