Ontology highlight
ABSTRACT:
SUBMITTER: Sen S
PROVIDER: S-EPMC7047529 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Sen Supriya S Cheng Zhang Z Sheu Katherine M KM Chen Yu Hsin YH Hoffmann Alexander A
Cell systems 20200122 2
Pathogen-derived lipopolysaccharide (LPS) and cytokine tumor necrosis factor (TNF) activate NFκB with distinct duration dynamics, but how immune response genes decode NFκB duration to produce stimulus-specific expression remains unclear. Here, detailed transcriptomic profiling of combinatorial and temporal control mutants identified 81 genes that depend on stimulus-specific NFκB duration for their stimulus-specificity. Combining quantitative experimentation with mathematical modeling, we found t ...[more]