Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC7047589 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Liu Yang Y Nguyen Phong T PT Wang Xun X Zhao Yuting Y Meacham Corbin E CE Zou Zhongju Z Bordieanu Bogdan B Johanns Manuel M Vertommen Didier D Wijshake Tobias T May Herman H Xiao Guanghua G Shoji-Kawata Sanae S Rider Mark H MH Morrison Sean J SJ Mishra Prashant P Levine Beth B
Nature 20200212 7796
The activation of adenosine monophosphate-activated protein kinase (AMPK) in skeletal muscle coordinates systemic metabolic responses to exercise<sup>1</sup>. Autophagy-a lysosomal degradation pathway that maintains cellular homeostasis<sup>2</sup>-is upregulated during exercise, and a core autophagy protein, beclin 1, is required for AMPK activation in skeletal muscle<sup>3</sup>. Here we describe a role for the innate immune-sensing molecule Toll-like receptor 9 (TLR9)<sup>4</sup>, and its int ...[more]