Advances in genetics toward identifying pathogenic cell states of rheumatoid arthritis.
Ontology highlight
ABSTRACT:
SUBMITTER: Amariuta T
PROVIDER: S-EPMC7047592 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Advances in genetics toward identifying pathogenic cell states of rheumatoid arthritis.
Amariuta Tiffany T Luo Yang Y Knevel Rachel R Okada Yukinori Y Raychaudhuri Soumya S
Immunological reviews 20191128 1
Rheumatoid arthritis (RA) risk has a large genetic component (~60%) that is still not fully understood. This has hampered the design of effective treatments that could promise lifelong remission. RA is a polygenic disease with 106 known genome-wide significant associated loci and thousands of small effect causal variants. Our current understanding of RA risk has suggested cell-type-specific contexts for causal variants, implicating CD4 + effector memory T cells, as well as monocytes, B cells and ...[more]
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