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Propagating wave activity in a tangential cortical slice.

ABSTRACT: Propagating neural waves in the cerebral cortex influence the integration of incoming sensory information with ongoing cortical activity. However, the neural circuit elements that support these cortical waves remain to be fully defined. Here, a novel tangential slice preparation was developed that exhibited propagating wave activity across the dorsal cortical sheet, as assessed using autofluorescence imaging following focal electrical stimulation. Analysis of functional connectivity in the slice preparation with laser-scanning photostimulation via glutamate uncaging revealed a lack of short-latency, presumed monosynaptic, long-range connections (>300 ?m) in the slice preparation. These results establish a novel slice preparation for assessing cortical dynamics and support the proposition that interactions among local cortical elements are sufficient to enable widespread propagating wave activity.

SUBMITTER: Lee CC

PROVIDER: S-EPMC7047729 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Propagating wave activity in a tangential cortical slice.

Lee Charles C CC

Neuroreport 20200301 4

Propagating neural waves in the cerebral cortex influence the integration of incoming sensory information with ongoing cortical activity. However, the neural circuit elements that support these cortical waves remain to be fully defined. Here, a novel tangential slice preparation was developed that exhibited propagating wave activity across the dorsal cortical sheet, as assessed using autofluorescence imaging following focal electrical stimulation. Analysis of functional connectivity in the slice ...[more]

PMID: 32058429

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