Metabolic Engineering of Bacillus licheniformis for Production of Acetoin.
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ABSTRACT:
SUBMITTER: Lu C
PROVIDER: S-EPMC7047894 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Metabolic Engineering of <i>Bacillus licheniformis</i> for Production of Acetoin.
Lü Chuanjuan C Ge Yongsheng Y Cao Menghao M Guo Xiaoting X Liu Peihai P Gao Chao C Xu Ping P Ma Cuiqing C
Frontiers in bioengineering and biotechnology 20200221
Acetoin is a potential platform compound for a variety of chemicals. <i>Bacillus licheniformis</i> MW3, a thermophilic and generally regarded as safe (GRAS) microorganism, can produce 2,3-butanediol with a high concentration, yield, and productivity. In this study, <i>B. licheniformis</i> MW3 was metabolic engineered for acetoin production. After deleting two 2,3-butanediol dehydrogenases encoding genes <i>budC</i> and <i>gdh</i>, an engineered strain <i>B. licheniformis</i> MW3 (Δ<i>budC</i>Δ<i ...[more]
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