Dataset Information

Validation of the global lung initiative 2012 multi-ethnic spirometric reference equations in healthy urban Zimbabwean 7-13?year-old school children: a cross-sectional observational study.

ABSTRACT:

Background

The 2012 Global Lung Function Initiative (GLI₂₀₁₂) provide multi-ethnic spirometric reference equations (SRE) for the 3-95?year-old age range, but Sub-Saharan African populations are not represented. This study aimed to evaluate the fit of the African-American GLI₂₀₁₂ SRE to a population of healthy urban and peri-urban Zimbabwean school-going children (7-13?years).

Methods

Spirometry and anthropometry were performed on black-Zimbabwean children recruited from three primary schools in urban and peri-urban Harare, with informed consent and assent. Individuals with a history or current symptoms of respiratory disease or with a body mass index-z score (BMI)?2012 SRE, which adjust for age, sex, ethnicity and height, after considering all GLI₂₀₁₂ modules. Anthropometry z-scores were generated using the British (1990) reference equations which adjust for age and sex. The African-American GLI₂₀₁₂ z-score distribution for the four spirometry measurements (FVC, FEV₁, FEV₁/FVC and MMEF) were evaluated across age, height, BMI and school (as a proxy for socioeconomic status) to assess for bias. Comparisons between the African-American GLI₂₀₁₂ SRE and Polgar equations (currently adopted in Zimbabwe) on the percent-predicted derived values were also performed.

Results

The validation dataset contained acceptable spirometry data from 712 children (344 girls, mean age: 10.5?years (SD 1.81)). The spirometry z-scores were reasonably normally distributed, with all means lower than zero but within the range of ±0.5, indicating a good fit to the African-American GLI₂₀₁₂ SRE. The African-American GLI₂₀₁₂ SRE produced z-scores closest to a normal distribution. Z-scores of girls deviated more than boys. Weak correlations (Pearson's correlation coefficient?2012 SRE provided a better fit for Zimbabwean paediatric spirometry data than Polgar equations.

Conclusion

The use of African-American GLI₂₀₁₂ SRE in this population could help in the interpretation of pulmonary function tests.

SUBMITTER: Madanhire T

PROVIDER: S-EPMC7048020 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Validation of the global lung initiative 2012 multi-ethnic spirometric reference equations in healthy urban Zimbabwean 7-13 year-old school children: a cross-sectional observational study.

Madanhire Tafadzwa T Ferrand Rashida A RA Attia Engi F EF Sibanda Elopy N EN Rusakaniko Simba S Rehman Andrea M AM

BMC pulmonary medicine 20200228 1

<h4>Background</h4>The 2012 Global Lung Function Initiative (GLI<sub>2012</sub>) provide multi-ethnic spirometric reference equations (SRE) for the 3-95 year-old age range, but Sub-Saharan African populations are not represented. This study aimed to evaluate the fit of the African-American GLI<sub>2012</sub> SRE to a population of healthy urban and peri-urban Zimbabwean school-going children (7-13 years).<h4>Methods</h4>Spirometry and anthropometry were performed on black-Zimbabwean children rec ...[more]

PMID: 32111226

Similar Datasets

Project description:BackgroundGood hearing is a fundamental skill that allows children to develop properly, both socially and intellectually. In contrast to defects in inner ear function, however, auditory processing disorders (APDs)-which can affect up to 2-3% of school-children-are not easily identified with basic screening programs and must be diagnosed using special tests. Although such psychoacoustic tests are available, the scores achieved depend highly on the social, cultural, and linguistic characteristics of the population, and norms must be established for each population separately. Reference values are still lacking for the Polish population, especially for children in school-age, so that practitioners must interpret test scores themselves, often intuitively or using potentially biased thresholds from other countries.Materials and methodsWe investigated a sample of 94 Polish schoolchildren with normal hearing, divided into four age groups: from 7 years-olds to 10 years-olds. All children had no speech or language development disorder, learning problem, or symptom of APD. Participants were volunteers who had previously taken part in a large screening study. The group consisted of 56 girls (60%) and 38 boys (40%) with an average age of 8.6 years (SD = 1.1). The test battery included the Duration Pattern Test (DPT), Frequency Pattern Test (FPT), Time-Compressed Speech Test (CST), and Dichotic Digit Test (DDT).ResultsThe scores on all tests increased consistently with age. The difference between each age-group for DPT, CST, and left- and right-ear DDT tests was significant (Kruskal-Wallis test, p-values = 0.002, 0.006, 0.005, 0.020, respectively), but the effect of age on the FPT test was not (p-value = 0.143). The analysis showed a clear and significant separation between a merged group of ages 7 and 8 and another of ages 9 and 10. We, therefore, propose, for each test, separate reference values for these two particular age-groups. Using thresholds based on a 10% quantile, we offer the following reference values for ages 7-8 and 9-10 respectively: DPT, 28.5% and 53.8%; FPT, 18.5% and 27.5%; CST, 68.6% and 77.2%; left-ear DDT, 34.3% and 52.5%; right-ear DDT, 56% and 72.5%.ConclusionThe scores on psychoacoustic tests to diagnose APD differ between cultures and linguistic backgrounds. Clinicians should, therefore, use norms that have been designed for the population most similar to their patients. Here, we report the use of a test battery designed for the Polish language that accounts for various aspects of APD when screening school children. Together with a full methodology of those tests, we provide norms that can be used as cut-offs in clinical diagnosis. Practitioners are invited to use them to obtain more accurate, evidence-based decisions.