The glycoprotein mucin-1 negatively regulates GalNAc transferase 5 expression in pancreatic cancer.
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ABSTRACT:
SUBMITTER: Caffrey T
PROVIDER: S-EPMC7048170 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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The glycoprotein mucin-1 negatively regulates GalNAc transferase 5 expression in pancreatic cancer.
Caffrey Thomas T Sagar Satish S Thomas Divya D Lewallen Michelle E ME Hollingsworth Michael A MA Radhakrishnan Prakash P
FEBS letters 20190721 19
Aberrant expression of the glycoprotein mucin-1 (MUC1) has been associated with pancreatic cancer progression and metastasis as a result of mediating the oncogenic transcriptional regulation of target genes. In the present study, we demonstrate that MUC1 downregulates the expression of the tumor suppressor polypeptide N-acetylgalactosaminyltransferase 5 in pancreatic cancer. ChIP-on-chip analysis revealed that the MUC1 cytoplasmic tail binds to regulatory elements in the GALNT5 gene. Additionall ...[more]
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