Ontology highlight
ABSTRACT:
SUBMITTER: Koshi-Mano K
PROVIDER: S-EPMC7048733 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Koshi-Mano Kagari K Mano Tatsuo T Morishima Maho M Murayama Shigeo S Tamaoka Akira A Tsuji Shoji S Toda Tatsushi T Iwata Atsushi A
Scientific reports 20200228 1
Histone modifications govern chromatin structures and regulate gene expression to orchestrate cellular functions in the central nervous system, where neuronal cells are postmitotic and developmentally inactive, the functional and age-dependent changes also accumulate in the epigenetic states. Because the brain is composed of several types of cells, such as the neurons, glial cells, and vascular cells, the analysis of histone modifications using bulk brain tissue might obscure alterations specifi ...[more]