Loss of angiogenin function is related to earlier ALS onset and a paradoxical increase in ALS duration.

ABSTRACT: 0.5-1% of ALS (Amyotrophic Lateral Sclerosis) and Parkinson's disease (PD) are associated with mutations in the angiogenin (ANG). These mutations are thought to cause disease through a loss of ANG function, but this hypothesis has not been evaluated statistically. In addition, the potential for ANG to promote disease has not been considered. With the goal of better defining the etiology of ANG-ALS, we assembled all clinical onset and disease duration data and determined if these were correlated with biochemical properties of ANG variants. Loss of ANG stability and ribonuclease activity were found to correlate with early ALS onset, confirming an aspect of the prevailing model of ANG-ALS. Conversely, loss of ANG stability and ribonuclease activity correlated with longer survival following di

SUBMITTER: Aluri KC 

PROVIDER: S-EPMC7048737 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature