Ontology highlight
ABSTRACT:
SUBMITTER: Manville RW
PROVIDER: S-EPMC7048750 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Manville Rίan W RW Abbott Geoffrey W GW
Communications biology 20200228 1
Potassium channels form physical complexes with solute transporters in vivo, yet little is known about their range of possible signaling modalities and the underlying mechanisms. The KCNQ2/3 potassium channel, which generates neuronal M-current, is voltage-gated and its activity is also stimulated by binding of various small molecules. KCNQ2/3 forms reciprocally regulating complexes with sodium-coupled myo-inositol transporters (SMITs) in mammalian neurons. Here, we report that the neurotransmit ...[more]