T-cell subset abnormalities predict progression along the Inflammatory Arthritis disease continuum: implications for management.
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ABSTRACT:
SUBMITTER: Ponchel F
PROVIDER: S-EPMC7048829 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
T-cell subset abnormalities predict progression along the Inflammatory Arthritis disease continuum: implications for management.
Ponchel Frederique F Burska Agata N AN Hunt Laura L Gul Hanna H Rabin Thibault T Parmar Rekha R Buch Maya H MH Conaghan Philip G PG Emery Paul P
Scientific reports 20200228 1
The presence of a disease continuum in inflammatory arthritis (IA) is a recognised concept, with distinct stages from at-risk stage (presence of anti citrullinated-peptide autoantibody) to diagnosis of rheumatoid arthritis (RA), including therapy-induced remission. Despite T-cell dysregulation being a key feature of RA, there are few reports of T-cell phenotyping along the IA-continuum. We investigated the disturbances of naïve, regulatory and inflammation related cell (IRC) CD4+ T-cell subsets ...[more]
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